Knowledge Tree
Relations (1)
cross_type 3.46 — strongly supporting 10 facts
Bruce S. McEwen is related to homeostasis because he developed an integration model that defines homeostasis as the essential physiological state maintained by the adaptive process of allostasis {fact:1, fact:7, fact:10}. He explicitly refined the concept to distinguish it as the stability of core vital parameters, contrasting it with the dynamic adjustments required for survival {fact:2, fact:6, fact:8, fact:9}.
Facts (10)
Sources
Allostasis revisited: A perception, variation, and risk framework frontiersin.org 4 facts
claimBruce McEwen (1998) suggests that chronically elevated glucocorticoid levels may cause imbalances in sympathetic and parasympathetic tone, as well as hormones associated with homeostasis, food intake, and reproduction, which may manifest as conditions like hypertension and insulin resistance.
quoteBruce McEwen stated that "homeostasis should be reserved for parameters that are essential to maintain for survival."
claimBruce McEwen and Eliot Stellar featured "allostasis" centrally in their work, but they focused on set-point-shifts as the core of their definition and explicitly retained homeostasis as a "tried and useful concept" that did not merit outright replacement.
claimBruce McEwen clarified in 2004 that the term 'homeostasis' should be reserved for physiological parameters that are essential to maintain for survival.
Homeostasis vs Allostasis — The Urban Health Council urbanhealthcouncil.com 3 facts
claimIn McEwen's model, homeostasis maintains the stability of core tissue parameters like pH and temperature, while allostasis dynamically modifies pericellular parameters like blood pressure and oxygen to support that stability.
claimMcEwen proposed a unifying model where allostasis is complementary to homeostasis, acting as the process that maintains homeostasis through dynamically changing physiological parameters such as blood pressure and heart rate to respond to environmental demands.
claimMcEwen distinguishes homeostasis as the basis of survival, whereas allostasis is a process that allows for adaptation over time.
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au 2 facts
referenceBruce McEwen's integration model defines homeostasis as the outcome of maintaining core vital parameters, while allostasis is the process of dynamic, multi-system coordination that enables homeostasis to occur despite changing environmental conditions.
claimBruce McEwen refined an integration model that recognizes homeostasis and allostasis as complementary concepts rather than competing ones.
Homeostasis or Allostasis? - Beauty, Neuroscience & Architecture neuro-architectology.com 1 fact
quoteAchim Peters and Bruce McEwen describe allostasis as an “active process by which living organisms adapt to potential threats to their survival and changes in their environment (often referred to as ‘stressors’) in order to maintain homeostasis and promote survival.”