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Relations (1)
related 2.00 — strongly supporting 3 facts
MDMA is directly linked to neurons through studies examining its impact on neurogenesis, where high doses are associated with decreased survival and proliferation of new neurons as noted in [1] and [2], while other research investigates potential growth abnormalities in these cells as described in [3].
Facts (3)
Sources
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 3 facts
claimResearchers in the study by Hernández-Rabaza et al. found no difference in potential abnormalities in the growth of new neurons between MDMA-treated rats and the control group.
measurementCatlow et al. (2010) reported that MDMA treatment reduced the survival of new neurons in rats by approximately 40–50%, as determined by co-labeling BrdU and NeuN.
claimMDMA exhibits dose-dependent effects on neurogenesis, where high doses are linked to decreased proliferation and survival of new neurons, potentially leading to neurotoxic outcomes.