inflammation ↔ senescence-associated secretory phenotype

Relations (1)

related 2.32 — strongly supporting 4 facts

The senescence-associated secretory phenotype (SASP) is a primary driver of inflammation in various pathological contexts, including chronic wounds [1], chronic kidney disease [2], and skin ageing [3]. Furthermore, therapeutic interventions that reduce SASP factors have been shown to concurrently decrease inflammation, as evidenced by anti-PD-1/PD-L1 administration [4].

Facts (4)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 4 facts

claimSenescent skin cells, senescence-associated secretory phenotype (SASP), oxidative stress, inflammation, and autophagy mediate the pathophysiology of skin ageing.

claimCellular senescence, stress-induced premature ageing, the senescence-associated secretory phenotype (SASP), oxidative stress, and inflammation contribute to the development of chronic kidney disease (CKD).

claimAnti-PD-1/PD-L1 administration ameliorates age-associated functional decline in vivo, including decreased senescence-associated secretory phenotypes (SASPs) and inflammation, while improving alveolar volume, liver fat accumulation, grip strength, and athletic ability.

claimIn chronic wounds, the interaction between senescent cells and the extracellular matrix is a barrier to healing because senescent cells produce Senescence-Associated Secretory Phenotype (SASP) factors and Reactive Oxygen Species (ROS), which increase matrix proteolysis, cause inflammation, impair vascular endothelial cells, and create a microenvironment that accelerates further cellular senescence.