inflammation ↔ macrophages

Relations (1)

related 13.00 — strongly supporting 12 facts

Macrophages are intrinsically linked to inflammation as they initiate it by recognizing harmful stimuli via PRRs [1], secrete cytokines that recruit immune cells and cause inflammation {fact:6, fact:9}, and also produce anti-inflammatory cytokines like IL-10 and IL-1Ra to resolve it {fact:1, fact:4, fact:7}.

Facts (12)

Sources

The Role of Immune Cells in Inflammation jmolpat.com Lukas Freund · Journal of Molecular Pathophysiology 3 facts

claimMacrophages and other immune cells produce anti-inflammatory cytokines, such as Interleukin-10 (IL-10), to promote the resolution of inflammation and tissue repair.

claimInnate immune cells, specifically macrophages, dendritic cells, and neutrophils, initiate the pathophysiological processes of inflammation by using Pattern Recognition Receptors (PRRs) to recognize harmful stimuli.

claimNeutrophils are among the first immune cells to arrive at the site of inflammation, attracted by chemokines produced by activated macrophages and other immune cells.

Parts of the Immune System | Children's Hospital of Philadelphia chop.edu Children's Hospital of Philadelphia 2 facts

claimMacrophages primarily destroy pathogens, signal the innate immune response, and cause inflammation, though they are also capable of serving as antigen-presenting cells.

claimThe secretion of cytokines by macrophages recruits other immune cells to the area, which leads to inflammation.

Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 2 facts

claimDuring the progression of inflammation from acute to chronic, the composition of white blood cells changes as macrophages and lymphocytes replace short-lived neutrophils.

claimOnce circulating leukocytes enter a local injury site, they are activated by cytokines and chemokines secreted by macrophages and dendritic cells, subsequently releasing their own cytokines and mediators of inflammation.

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 2 facts

claimIL-1Ra is secreted by neutrophils, macrophages, monocytes, and hepatocytes to decrease inflammation.

referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.

Understanding the Stages of Wound Healing healogics.com Healogics 1 fact

claimMacrophages continue the clean-up work started by neutrophils, promote new tissue growth by releasing growth factors, and play a vital role in reducing and resolving inflammation.

The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov Janeway CA Jr, Travers P, Walport M · Garland Science 1 fact

claimMacrophages and mast cells complete their differentiation in tissues, where they function as effector cells in host defense and initiate inflammation.

Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute 1 fact

referenceOlefsky JM and Glass CK published a review titled 'Macrophages, inflammation, and insulin resistance' in the Annual Review of Physiology, volume 72, pages 219-246.