Justification not yet generated — showing supporting facts

• Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are released from the anterior pituitary gland and modulate the production of hormones in the testes.
• Reinberg et al. (38) studied 260 men undergoing vasectomy in France (median age 32 years) and found annual peaks for testosterone and LH in autumn, and an annual peak for FSH in summer.
• Follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone are the primary hormones that regulate the functions of the female reproductive system.
• The menstrual cycle is regulated by the hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and progesterone.
• Gonadotropin-releasing hormone (GnRH), produced by the hypothalamus, regulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland.
• Inclusion criteria for the study required male patients to be older than 18 years and to have testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) measured in the same venous blood sample taken in the morning after an overnight fast.
• Total serum testosterone levels are directly related to luteinizing hormone (LH) (R = 0.147, p < 0.001), but not to follicle-stimulating hormone (FSH) (R = -0.006, p = 0.482).
• The onset of male puberty is stimulated by a rise in gonadotropin-releasing hormone (GnRH) from the hypothalamus, which triggers the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
• Sawhney et al. (39) studied 9 healthy men in Antarctica and found bi-annual peaks for testosterone in summer and autumn, with no seasonality detected for LH or FSH.
• Secondary hypogonadism in human males results from a disruption in the hypothalamic-pituitary axis where low gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH) leads to low testosterone and impaired spermatogenesis.
• The pituitary gland secretes follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during sleep, which are important for regulating the reproductive system.
• Follicle-stimulating hormone and luteinizing hormone affect the ovaries and uterus, initiating the monthly reproductive cycles.
• The study 'Seasonal Changes of Serum Gonadotropins and Testosterone in...' analyzed testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) measurements collected between January 2010 and January 2019 using Chemiluminescent Microparticle Immunoassay, excluding subjects with factors interfering with the hypothalamic-pituitary-gonadal axis.
• Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) trigger an increase in estrogen production in the ovaries.
• Prolactin (PRL) serum levels in adult human males do not correlate with testosterone (Rho: 0.002, p = 0.804), luteinizing hormone (Rho: 0.005, p = 0.665), or follicle-stimulating hormone (Rho: 0.006, p = 0.734).
• Sleep is associated with the secretion and regulation of hormones from several endocrine glands, including melatonin, follicle stimulating hormone (FSH), luteinizing hormone (LH), and growth hormone, according to the National Institutes of Health.
• FSH and LH exert their physiological effects by binding to and activating a G protein receptor, which activates adenylyl cyclase and increases cellular cAMP levels to stimulate Sertoli and Leydig cells.
• The pituitary gland produces, stores, and stimulates Human Chorionic Gonadotropin (HcG), Prolactin, Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH).
• Estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) regulate the menstrual cycle by signaling the brain, ovaries, and uterus.
• The luteinizing hormone (LH) surge stimulates the luteinization of granulosa cells and the synthesis of progesterone, which is responsible for the midcycle follicle-stimulating hormone (FSH) surge.
• The female menstrual cycle relies on Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), estrogen, and progesterone for regularity.
• After the onset of puberty, the hypothalamus releases GnRH in a pulsatile fashion every one to two hours to maintain levels of FSH, LH, and plasma testosterone.
• Women experience monthly hormonal cycles tied to the menstrual cycle, which typically lasts 28 days and is regulated by estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
• In the presence of estradiol, follicle-stimulating hormone (FSH) stimulates the formation of luteinizing hormone (LH) receptors on granulosa cells, allowing for the secretion of small quantities of progesterone and 17-hydroxyprogesterone (17-OHP), which may exert a positive feedback on the estrogen-primed pituitary to augment LH release.
• Meriggiola et al. (1996) examined annual patterns of luteinizing hormone, follicle-stimulating hormone, testosterone, and inhibin in normal men.
• Abbaticchio et al. (27) studied 248 infertile men in Italy (mean age 28.9 ± 7.5 years) and detected no seasonality for testosterone, LH, or FSH.
• GnRH stimulates the anterior pituitary by binding to and activating a G protein receptor on gonadotrophs, which triggers inositol 1,4,5-triphosphate (IP3) activation and increases intracellular calcium, leading to the release of FSH (follicle-stimulating hormone) and LH (luteinizing hormone).
• The anterior pituitary secretes LH and FSH into the blood, which act on membrane receptors in the Leydig and Sertoli cells of the testes, respectively.
• Serum luteinizing hormone (LH) is directly related to follicle-stimulating hormone (FSH) (R = 0.538, p < 0.001).
• Patient age is inversely related to serum testosterone levels (R = -0.148, p < 0.001) and directly related to luteinizing hormone (LH) (R = 0.185, p < 0.001) and follicle-stimulating hormone (FSH) (R = 0.281, p < 0.001).
• Women experience monthly hormonal cycles tied to the menstrual cycle, which typically lasts 28 days and is regulated by estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
• The pituitary gland in women releases follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to prepare the body for pregnancy during the menstrual cycle.
• The researchers evaluated the distribution of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) based on the date of examination using autocorrelation analyses.
• Bellastella et al. (28) studied 106 pre-pubertal males in Italy (age range 6–10 years) and found an annual peak for testosterone in summer and an annual peak for LH in winter, with no seasonality detected for FSH.
• Testosterone, LH, and FSH levels in the study cohort were not normally distributed (p < 0.001).
• Erickson G.F., Wang C., and Hsueh A.J. published a study in 1979 in the journal Nature titled 'FSH induction of functional LH receptors in granulosa cells cultured in a chemically defined medium', which details the induction of luteinizing hormone receptors by follicle-stimulating hormone.
• Nicolau et al. (36) studied 63 healthy men in Romania (mean age 77.0 ± 8.0 years) and found annual peaks for testosterone and LH, but no seasonality for FSH.
• Elevated follicle-stimulating hormone (FSH) levels at midcycle are thought to free the oocyte from follicular attachments, stimulate plasminogen activator, and increase granulosa cell luteinizing hormone (LH) receptors.
• Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured using Chemiluminescent Microparticle Immunoassay (Architect, Abbott, Longford, Ireland). The inter- and intra-assay coefficients of variation were 4.1% and 3.1% for LH, and 4.6% and 4.2% for FSH, respectively.
• The luteinizing hormone (LH) surge stimulates the luteinization of granulosa cells and the synthesis of progesterone, which is responsible for the midcycle follicle-stimulating hormone (FSH) surge.
• FSH and LH belong to the same glycoprotein family and consist of identical alpha subunits, but are differentiated by their unique beta-subunits.
• Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) promote ovulation and stimulate the ovaries to secrete the sex hormones estradiol (an estrogen) and progesterone.
• Bellastella et al. (29) studied 10 healthy men in Italy (age range 25–30 years) and found an annual peak for testosterone in autumn and an annual peak for LH in spring, with no seasonality detected for FSH.
• The menstrual cycle is guided by shifts in estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
• Prepubertal males exhibit circannual rhythms of plasma luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin, and cortisol, according to a 1983 study by Bellastella et al.
• The menstrual cycle is regulated by fluctuations in the hormones estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
• Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) promote ovulation in the female reproductive system.
• During the follicular phase of the menstrual cycle, the brain releases follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which travel through the blood to the ovaries to stimulate the growth of 15 to 20 eggs, each contained within a follicle.
• Testosterone acts on the hypothalamus and anterior pituitary via negative feedback to decrease the secretion of LH and FSH.
• Gonadotropin-releasing hormone (GnRH) travels to the anterior pituitary gland, where it activates G protein–coupled receptors, signaling the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH).