Follicle-stimulating hormone ↔ testosterone

Relations (1)

related 4.25 — strongly supporting 18 facts

Testosterone and Follicle-stimulating hormone (FSH) are interconnected in male reproductive physiology, as both stimulate Sertoli cells to release androgen-binding protein during spermatogenesis [1], and testosterone exerts negative feedback on the hypothalamus and pituitary to decrease FSH secretion [2]. Numerous studies measure and analyze their serum levels together, revealing correlations with age [3], direct relationships with LH [4], and seasonal patterns [5], [6], [7], [8].

Facts (18)

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Seasonal Changes of Serum Gonadotropins and Testosterone in ... frontiersin.org Frontiers 15 facts

measurementReinberg et al. (38) studied 260 men undergoing vasectomy in France (median age 32 years) and found annual peaks for testosterone and LH in autumn, and an annual peak for FSH in summer.

procedureInclusion criteria for the study required male patients to be older than 18 years and to have testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) measured in the same venous blood sample taken in the morning after an overnight fast.

measurementTotal serum testosterone levels are directly related to luteinizing hormone (LH) (R = 0.147, p < 0.001), but not to follicle-stimulating hormone (FSH) (R = -0.006, p = 0.482).

measurementSawhney et al. (39) studied 9 healthy men in Antarctica and found bi-annual peaks for testosterone in summer and autumn, with no seasonality detected for LH or FSH.

procedureThe study 'Seasonal Changes of Serum Gonadotropins and Testosterone in...' analyzed testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) measurements collected between January 2010 and January 2019 using Chemiluminescent Microparticle Immunoassay, excluding subjects with factors interfering with the hypothalamic-pituitary-gonadal axis.

claimProlactin (PRL) serum levels in adult human males do not correlate with testosterone (Rho: 0.002, p = 0.804), luteinizing hormone (Rho: 0.005, p = 0.665), or follicle-stimulating hormone (Rho: 0.006, p = 0.734).

referenceMeriggiola et al. (1996) examined annual patterns of luteinizing hormone, follicle-stimulating hormone, testosterone, and inhibin in normal men.

measurementAbbaticchio et al. (27) studied 248 infertile men in Italy (mean age 28.9 ± 7.5 years) and detected no seasonality for testosterone, LH, or FSH.

measurementPatient age is inversely related to serum testosterone levels (R = -0.148, p < 0.001) and directly related to luteinizing hormone (LH) (R = 0.185, p < 0.001) and follicle-stimulating hormone (FSH) (R = 0.281, p < 0.001).

procedureThe researchers evaluated the distribution of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) based on the date of examination using autocorrelation analyses.

measurementBellastella et al. (28) studied 106 pre-pubertal males in Italy (age range 6–10 years) and found an annual peak for testosterone in summer and an annual peak for LH in winter, with no seasonality detected for FSH.

measurementTestosterone, LH, and FSH levels in the study cohort were not normally distributed (p < 0.001).

measurementNicolau et al. (36) studied 63 healthy men in Romania (mean age 77.0 ± 8.0 years) and found annual peaks for testosterone and LH, but no seasonality for FSH.

measurementBellastella et al. (29) studied 10 healthy men in Italy (age range 25–30 years) and found an annual peak for testosterone in autumn and an annual peak for LH in spring, with no seasonality detected for FSH.

referencePrepubertal males exhibit circannual rhythms of plasma luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin, and cortisol, according to a 1983 study by Bellastella et al.

Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 3 facts

claimSecondary hypogonadism in human males results from a disruption in the hypothalamic-pituitary axis where low gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH) leads to low testosterone and impaired spermatogenesis.

claimFSH and testosterone stimulate Sertoli cells, located in the periphery of the seminiferous tubules of the testes, to release androgen-binding protein (ABP), which provides testosterone to germ cells during spermatogenesis.

claimTestosterone acts on the hypothalamus and anterior pituitary via negative feedback to decrease the secretion of LH and FSH.