Knowledge Tree
Relations (1)
related 2.32 — strongly supporting 4 facts
Macrophages are directly linked to anti-inflammatory cytokines as they are primary producers of these molecules, including IL-10 and IL-38, as described in [1], [2], and [3]. Additionally, macrophages serve as both producers and targets for specific anti-inflammatory cytokines like IL-12, as noted in [4].
Facts (4)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 3 facts
referenceIL-12 is classified as an anti-inflammatory cytokine, is produced by T cells, macrophages, and monocytes, binds to the CD212 receptor, targets NK cells, macrophages, and tumor cells, and functions in activating NK cells, phagocyte cell activation, endotoxic shock, tumor cytotoxicity, and cachexia.
referenceIL-10 is classified as an anti-inflammatory cytokine, is produced by T cells, B cells, and macrophages, binds to the CDw210 receptor, targets B cells and macrophages, and functions to inhibit cytokine production and mononuclear cell function.
claimInterleukin-38 (IL-38/IL-1F10) is an anti-inflammatory cytokine produced by B cells and macrophages that binds to the IL-1R1 receptor.
The Role of Immune Cells in Inflammation jmolpat.com 1 fact
claimMacrophages and other immune cells produce anti-inflammatory cytokines, such as Interleukin-10 (IL-10), to promote the resolution of inflammation and tissue repair.