Knowledge Tree
Relations (1)
related 2.00 — strongly supporting 3 facts
Macrophages and eosinophils are both identified as immune cells capable of releasing cytokines [1] and are specifically noted as producers of IL-6 upon stimulation [2]. Furthermore, they are functionally linked through the cytokine GM-CSF, which regulates the growth of macrophages and the production of eosinophils [3].
Facts (3)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 2 facts
claimIL-6 is produced by monocytes, fibroblasts, and endothelial cells, and upon stimulation, it is secreted by macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes.
referenceGM-CSF is classified as an adaptive immunity cytokine, is produced by T cells, macrophages, and fibroblasts, binds to CD116 and CDw131 receptors, targets stem cells, and functions in the growth and differentiation of monocytes and the production of eosinophils and granulocytes.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org 1 fact
claimImmune cells that release cytokines include macrophages, dendritic cells, lymphocytes (T and B lymphocytes), monocytes, neutrophils, basophils, eosinophils, and mast cells.