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Relations (1)
related 3.00 — strongly supporting 7 facts
Macrophages are a primary cellular source of interleukin-6, as they secrete it upon stimulation [1], [2], [3], and [4]. Furthermore, macrophages produce cytokines that regulate the activity of interleukin-6 [5], and the interleukin-6 produced by macrophages plays a key role in systemic inflammatory responses [6].
Facts (7)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 4 facts
procedureMacrophages and endothelial cells produce large amounts of IL-6 after activation, which activates T cells and other immune cells, creating a positive feedback loop that results in a cytokine storm, the release of additional cytokines and chemokines, and the upregulation of acute phase proteins.
claimIL-6 is produced by monocytes, fibroblasts, and endothelial cells, and upon stimulation, it is secreted by macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes.
referenceIL-6 is classified as a pro-inflammatory cytokine, is produced by Th cells, macrophages, and fibroblasts, binds to CD126 and CD130 receptors, targets B cells and plasma cells, and functions in B-cell differentiation.
claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 2 facts
claimCytokines produced by macrophages have systemic effects: IL-1 induces fever, TNF-alpha causes wasting (cachexia), IL-6 induces liver production of acute phase proteins, and IL-3 increases neutrophil maturation and release from bone marrow.
claimMacrophages produce major cytokines including TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-33.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
measurementIn a randomized, double-blind, placebo-controlled trial involving 46 healthy older adults (ages 55 to 75 years), daily supplementation with 720 mg of EPA and 280 mg of DHA for 12 weeks had no effect on the numbers of neutrophils, monocytes, or macrophages, nor did it affect respiratory burst or the production of cytokines TNF-α, IL-1β, and IL-6.