Knowledge Tree
Relations (1)
related 3.00 — strongly supporting 4 facts
Chemotherapy and endocrine therapy are both standard modalities in modern breast cancer treatment [1], [2], and research studies have directly compared their long-term impacts on the physical health of cancer survivors [3], [4], [5], including the synergistic decline observed when both are used in combination [6].
Facts (4)
Sources
Crucial Answers on Long-Term Physical Health Effects From Breast ... cancernetwork.com 4 facts
claimClara Bodelon, PhD, MS, a senior principal scientist of survivor research at the American Cancer Society, published a study in JAMA Network Open indicating that chemotherapy leads to more significant long-term physical health declines in breast cancer patients compared to endocrine therapy.
referenceBodelon C, Masters M, Bloodworth DE, et al. published a study titled 'Physical health decline after chemotherapy or endocrine therapy in breast cancer survivors' in JAMA Network Open on February 3, 2025 (doi:10.1001/jamanetworkopen.2024.62365).
measurementA study published by Clara Bodelon in JAMA Network Open found that the greatest decline in physical health among breast cancer survivors occurred with the combination of chemotherapy and endocrine therapy (β = −1.34; 95% CI, −2.07 to −0.61).
claimCancer survivors who received chemotherapy, regardless of whether they also received endocrine therapy, are more likely to suffer long-term physical health declines compared to those who did not receive chemotherapy.