Knowledge Tree
Relations (1)
related 2.00 — strongly supporting 3 facts
The brain and gut are linked through the 'expensive tissue hypothesis,' which suggests that a higher-quality diet allowed for the evolution of smaller guts to provide energy for a larger brain [1]. Additionally, they maintain a bidirectional communication pathway to signal bodily threats [2] and are both targets for therapeutic interventions involving HCN2 channel-induced rescue [3].
Facts (3)
Sources
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org 1 fact
claimThe brain and the gut communicate by sending signals to each other to alert the body of threats.
The Evolution of Diet - National Geographic nationalgeographic.com 1 fact
claimLeslie Aiello and Peter Wheeler proposed that the consumption of a higher-quality diet with less bulky plant fiber allowed Homo erectus to develop smaller guts, which freed up energy to fuel a larger brain.
Bioelectricity - The Levin Lab drmichaellevin.org 1 fact
referencePai, V. P., and Levin, M. (2022) demonstrated that HCN2 channel-induced rescue can mitigate brain, eye, heart, and gut teratogenesis caused by nicotine, ethanol, and aberrant Notch signaling.