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• Psychedelics elevate synaptic efficacy and neuroplasticity through their agonist action at 5-HT2A receptors, as reported by Ly et al. in 2018.
• Future research in psychedelic therapy aims to address the relationship between acute drug effects and longer-term clinical effects, the characterization of 5-HT2A receptor effects, and the impact of these compounds on neuroplasticity.
• Clinical studies in psychedelic therapy aim to establish a 'molecular-functional-clinical bridge' by characterizing the relationship between acute and longer-term clinically-relevant effects, investigating the 5-HT2A receptor's association with functional and clinical effects, and focusing on neuroplasticity.
• The neural plasticity effects of DOI and 25I-NBOMe are primarily mediated through serotonin receptors, specifically 5-HT2A and 5-HT2B.