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Cytokines are signaling molecules released by the immune system to detect, signal, and combat an infection, as evidenced by their role in directing immune cells to infection sites [1], [2], and their release by white blood cells to fight germs [3], [4].

Facts (12)

Sources
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org Cleveland Clinic 6 facts
claimCytokine release syndrome (CRS), also called a cytokine storm, is a condition that may develop if the immune system releases too many cytokines in response to an infection or treatments like immunotherapy.
claimCytokines signal cell differentiation by instructing immature cells to develop into specific cell types, such as instructing an immature cell to mature into a white blood cell capable of fighting infection.
claimCytokines signal cell activation by directing immune cells toward infection sites to fight germs and by heightening or lessening processes associated with inflammation.
claimCytokines are essential components of a healthy immune system, as they act as signaling molecules that help maintain an infection-free state when present in the correct amounts.
claimCytokines signal cell proliferation by instructing a cell to replicate itself, such as telling a white blood cell to produce more white blood cells to fight infection.
claimChemokines are a type of cytokine that direct immune cells toward locations in the body where they can fight infection.
Understanding chronic inflammation: Causes, symptoms and ... uhc.com UnitedHealthcare 1 fact
claimWhen the body detects an injury or a foreign substance like a virus, it releases inflammatory cells and cytokines to the affected area to eliminate the threat and protect against infection.
How the Immune System Works with Primary Immunodeficiency igcares.com IGCares 1 fact
claimWhen a cell is infected by a virus, the cell releases cytokines to alert other cells to the infection, which generally prevents those other cells from becoming infected.
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu Vanderbilt University 1 fact
claimWhite blood cells, such as granulocytes and macrophages, act as first responders to sites of infection and injury by emitting chemicals to kill germs and releasing protein messengers called cytokines.
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Cedars-Sinai 1 fact
claimMacrophages, which are cells whose name means 'big eaters' in Greek, release compounds called cytokines to signal immune reinforcements to a site of injury or infection.
Inflammation bioxpedia.com BioXpedia 1 fact
claimInflammation is the immune system's primary response to infection and foreign substances, such as bacteria and viruses, involving the release of cytokines from white blood cells into the blood or affected tissues.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute 1 fact
claimSoluble factors, including cytokines, are responsible for recruiting phagocytic cells to local areas of infection.