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Relations (1)
related 2.00 — strongly supporting 3 facts
Ketamine and benzodiazepines are related because clinical research, such as the RAPID study [1] and reports by Andrashko et al. [2], indicates that benzodiazepines can undermine or dampen the antidepressant efficacy of ketamine. Consequently, clinical protocols like the Montreal model recommend tapering benzodiazepines prior to ketamine treatment to avoid these negative interactions [3].
Facts (3)
Sources
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 3 facts
procedureThe Montreal model clinical team proposes a trial of benzodiazepine and related sedative (BZDR) discontinuation for all patients, which typically entails a slow taper such that final doses occur within several days of the first ketamine treatment, due to evidence that benzodiazepines may dampen or shorten the antidepressant effects of ketamine.
claimThe RAPID intravenous ketamine study, published by Feeney et al. in the Journal of Clinical Psychiatry in 2022, investigated the effect of concomitant benzodiazepines on the antidepressant effects of ketamine.
claimAndrashko et al. reported in European Neuropsychopharmacology in 2019 that concurrent benzodiazepines undermine the antidepressant effect of ketamine.