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Relations (1)
related 3.17 — strongly supporting 8 facts
Estradiol is a specific hormone classified as a member of the estrogen group, as explicitly stated in [1] and [2]. Furthermore, the dominant follicle secretes estrogen primarily in the form of estradiol [3], and both substances share physiological roles in inhibiting GnRH secretion [4] and influencing bone and vascular health [5].
Facts (8)
Sources
Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimTestosterone can be converted peripherally to estradiol via aromatase found in adipose tissue, and estradiol can subsequently be converted to estrogen.
claimThe secretion of GnRH is inhibited by testosterone, estrogen, estradiol, and prolactin.
claimEstradiol and estrogen play roles in bone resorption, epiphyseal closure, gynecomastia, and vascular effects, and they exert an inhibitory effect on the hypothalamus and anterior pituitary.
The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov 2 facts
claimThe dominant follicle secretes large quantities of estrogen, primarily estradiol, due to high levels of the enzyme CYP19 (aromatase).
referenceYoung J.R. and Jaffe R.B. published a study in 1976 in the journal J Clin Endocrinol Metab titled 'Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing hormone in women. II. Effects of varying concentrations of estradiol', which investigates the hormonal feedback mechanisms in women.
Female Reproductive Endocrinology - Gynecology and Obstetrics merckmanuals.com 2 facts
Reproductive Hormones endocrine.org 1 fact
claimEstrogen is a group of hormones, including estradiol, estriol, and estrone, that are important for growth and reproductive development in women.