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related 2.00 — strongly supporting 3 facts
Depression and depressive symptoms are intrinsically linked as the former is a clinical condition characterized by the latter, as evidenced by their joint investigation in clinical research [1]. Furthermore, the severity of depressive symptoms is used as a metric to measure the state of depression [2], and therapeutic interventions targeting biological markers in depression have been shown to directly alleviate these depressive symptoms [3].
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Integrating allostasis and emerging technologies to study complex ... nature.com 2 facts
claimPatients with depression show higher allostatic load indices compared to non-depressed controls, and cortisol levels in these patients positively correlate with the severity of depressive symptoms.
claimIn individuals with depression who exhibited elevated inflammatory markers, specifically C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α), treatment with the TNF-α antagonist infliximab led to improvements in depressive symptoms.
From Homeostasis to Allodynamic Regulation (Chapter 18) cambridge.org 1 fact
referenceKohler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., and Krogh, J. published 'Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials' in JAMA Psychiatry in 2014, volume 71, pages 1381–1391.