Knowledge Tree
Relations (1)
related 3.70 — strongly supporting 11 facts
Aging and inflammation are intrinsically linked as inflammation is a primary pathogenic feature that increases during the aging process [1], [2]. This relationship is further supported by shared signaling pathways and molecular mechanisms, such as NF-κB regulation and NAD+ synthesis, which influence both aging and inflammatory responses [3], [4], [5].
Facts (11)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com 5 facts
claimRestoring defective intercellular communications by inhibiting inflammation can rejuvenate aging-impaired changes, though long-term inflammation inhibition may result in immunosuppression.
referenceInflammation, epigenetics, and metabolism converge to influence cell senescence and aging, as described by Zhu et al. in a 2021 Signal Transduction and Targeted Therapy paper.
referenceLibby, P. and Kobold, S. published a study in 2019 titled 'Inflammation: a common contributor to cancer, aging, and cardiovascular diseases-expanding the concept of cardio-oncology' in Cardiovascular Research, which posits inflammation as a common factor contributing to cancer, aging, and cardiovascular diseases.
referenceMontaruli et al. (2020) published 'The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration' in Neurobiology of Disease, examining the intersection of aging, inflammation, and circadian rhythms in neurodegenerative conditions.
referenceJAK2 plays roles in aging, inflammation, hematopoiesis, and malignant transformation.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 3 facts
claimThe article "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" addresses the topics of cellular senescence, cancer, m6A RNA methylation, aging, longevity, and inflammation.
referenceMinhas P.S. et al. published 'Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation' in Nature Immunology in 2019, detailing how NAD+ synthesis affects immune function.
claimInflammation is linked to aging through specific signaling pathways, which are targets for intervention therapies.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org 1 fact
claimClonal hematopoiesis connects aging and inflammation in the context of cardiovascular disease, as discussed by Jaiswal and Libby in 2020.
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org 1 fact
claimAging is characterized by a low-grade, unresolved inflammation that persists in the background, rather than an acute, high-level immune response.
Should you be tested for inflammation? health.harvard.edu 1 fact
claimStamping out inflammation would not eliminate cardiovascular disease, cancer, dementia, or aging.