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Relations (1)

related 2.32 — strongly supporting 4 facts

Aging and disease are intrinsically linked through shared biological mechanisms such as cellular proteostasis [1], mitochondrial function [2], extracellular matrix dynamics [3], and NAD(+) metabolism [4].

Facts (4)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature 3 facts

referencePathways of cellular proteostasis in aging and disease are described in the 2018 paper 'Pathways of cellular proteostasis in aging and disease' published in the Journal of Cell Biology.

referenceMitochondria play a role in skin health, aging, and disease, as reported by Sreedhar, Aguilera-Aguirre, and Singh in their 2020 Cell Death & Disease paper.

referenceLongevity-promoting pathways and transcription factors respond to and control extracellular matrix dynamics during aging and disease, as discussed by Vidovic and Ewald in their 2022 Frontiers in Aging paper.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceThe article 'Regulation of NAD(+) metabolism in aging and disease' published in Metabolism: Clinical and Experimental in 2022 (126:154923) covers the regulation of NAD(+) metabolism in the context of aging and disease.