Knowledge Tree
Relations (1)
related 3.17 — strongly supporting 8 facts
Testosterone is the direct precursor to dihydrotestosterone (DHT), as it is converted into DHT by the enzyme 5-alpha-reductase [1], [2], [3], [4], and [5]. Both hormones are related through their shared interaction with androgen receptors [6] and their combined roles in physiological development and hormonal regulation [7], [8].
Facts (8)
Sources
Reproductive Hormones endocrine.org 4 facts
claimDihydrotestosterone is created when testosterone is converted into a new form.
claimDihydrotestosterone initiates puberty in boys, causing genital development, pubic and body hair growth, and prostate growth, and may contribute to the expression of sexual desires and behavior alongside testosterone.
claimHigh levels of dihydrotestosterone in women, stemming from excess testosterone production, can cause excess body and facial hair, adult acne, and menstruation issues.
measurementApproximately 10% of testosterone in the bodies of adult men and women is converted into dihydrotestosterone, with higher conversion rates occurring during puberty.
Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimThe enzyme 5-alpha-reductase, produced by the prostate, converts testosterone into dihydrotestosterone (DHT).
claimDihydrotestosterone (DHT) and testosterone bind to the same intracellular androgen receptors, but DHT has a higher affinity for these receptors.
claimIn the periphery, testosterone can be converted into dihydrotestosterone via the enzyme 5-alpha-reductase, or into estradiol via the enzyme aromatase.
The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov 1 fact
claimThe enzyme 5α-reductase converts testosterone to dihydrotestosterone (DHT), which cannot be aromatized.